Continued investigation of the loci listed in Table 2 is warranted, as other loci may provide the ability to quantify other aspects of smoking behavior, such as cessation time and remote smoking behavior [28,49,50,54,62], and may offer differential sensitivity and specificity in different ethnic groups [28]. In addition, although not the primary purpose of biomarker studies, detection of weaker signals may be useful in elucidating the underlying biology of smoking-associated disease, for example through the use of network and pathway analyses [27].
