Chunk #6 — Results — Association of traits with tissues using bulk-tissue RNA-seq

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Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease.

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We first aimed to identify the human tissues showing enrichment for genetic associations using bulk-tissue RNA-seq (37 tissues) from GTEx 8 (Figure 1). To robustly identify the tissues implied by these 26 GWAS, we used two approaches (MAGMA 23 and LDSC 13,24) which employ different assumptions (Methods). For both methods, we tested whether the 10% most specific genes in each tissue were enriched in genetic associations with the different traits (Figure 1B).