Chunk #21 — RESULTS — IRE1α utilizes a micro-RNA to control TXNIP levels

Source

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.

Embedded

yes

Text

3′-UTR reporter (Figure 3H). Together these results argue that activation of IRE1α increases TXNIP mRNA levels post-transcriptionally by reducing its inhibitory micro-RNA, miR-17. Rationalizing our results, a mathematical model (Figure S5J and K) shows that a combination of transcriptional and post-transcriptional control of TXNIP mRNA produces a sharper—and more rapid—rise to new steady-state levels upon ER stress than would occur through de novo mRNA synthesis alone.