Another limitation of our study lies in its cross‐sectional nature, which constrains our ability to assess individual‐level rates of change over time. However, despite this limitation, our findings align with those reported by Mishra et al. in a longitudinal study involving 497 cognitively normal middle to older age participants. 36 They categorized participants as either APOE ε4 carriers (ε3/ε4 or ε4/ε4) or non‐carriers (ε2/ε2, ε2/ε3, or ε3/ε3) and observed greater rate of hippocampal atrophy in APOE ε4 carriers relative to non‐carriers, with this effect first detected at age 57.
