In summary, there are limitations to our current ability to estimate the disease burden of alcohol. The CRA can only try to develop the best possible estimates given the current state of knowledge. It is likely that new confounders will be found for some of the relationships described above, and, as new evidence emerges, there will be additions to and deletions from the list of alcohol-related disease and injury categories. Nonetheless, these limitations cannot change the overall conclusion that alcohol is related to many disease outcomes, both chronic and acute, and causes a considerable part of the global burden of disease [66].
