Variations in amygdala activity have been related to clinical features of schizophrenia (Pinkham et al., 2007), particularly positive symptoms (Taylor et al., 2002; 2005) and the paranoid subtype (Pinkham et al., 2008; Williams et al., 2004). A smaller literature relating negative symptoms to amygdala activity has focused on flat affect (Fahim et al., 2005; Lepage et al., 2011). Abnormally increased amygdala activation to fearful faces was associated with incorrect identification and with more pronounced flat affect (Gur et al., 2007).
