Other research has identified links between genetic predispositions and RNA associations from human brain data on substance use disorders. Using a variety of different genomic methods, including gene-based associations, expression quantitative trait loci, and partitioned heritability, genetic associations with substance use disorders show overlap with differentially expressed genes and gene co-expression networks associated with these traits in post-mortem human brain data8–10. Thus, mRNA associations with AUD in human brain data—including alternative mRNA mis-splicing—could be due to drug exposure, genetic factors, or both.
