As part of the GO Reference Genome Project, GO curators are annotating trees from the PANTHER database with GO terms describing molecular function, biological process and cellular component. As described in (5), the goal of this project is to provide accurate, complete and consistent GO annotations for all genes in 12 model organism genomes. GO terms based on experimental data from the scientific literature are used to annotate ancestral genes in the phylogenetic tree; thus, unannotated descendants of these ancestral genes are inferred to have inherited these same GO annotations by descent. An example of this annotation process is shown in Figure 3.
