non-significant trend for an excess of the risk allele (A) in high neuroticism-score individuals. A family-based analysis revealed overtransmission of the A allele in high-score individuals from the Australian sample (p = 0.04), but not in the Netherlands sample. Thus, the association of rs702543 with neuroticism is notable but requires confirmation. In a genome-wide study of US-based and German samples, van den Oord [28] found association between neuroticism and four SNPs in the chr 14 gene MAMDC1 (combined p<10−6). To date, the most recent association study [29] failed to replicate an association between the candidate gene NPY and stress response and emotion (reported by Zhou [30], using instruments other than the EPQ).
