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Chunk #66 — Fig 3

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Integrating mRNA and miRNA Weighted Gene Co-Expression Networks with eQTLs in the Nucleus Accumbens of Subjects with Alcohol Dependence.
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(A). mRNA modules significantly correlated with AD case-status. Each point represents an individual transcript within each module, which are plotted by the absolute value of their expression correlation to AD case-status (Gene Significance) on the y-axis and module eigengene (Module Membership) on the x-axis. The regression line, correlation value and p-value is shown for each plot, which indicates that GS of transcripts increases with increasing intramodular connectivity (MM). (B). miRNA modules significantly correlated with AD case-status. Each point represents an individual miRNA transcript within each module, which are plotted by the absolute value of their expression correlation to AD case-status (Gene Significance) on the y-axis and module eigengene (Module Membership) on the x-axis. Similarly to mRNA modules, GS of miRNA transcripts increases with increasing intramodular connectivity (MM).