to examine the heritability estimates for TS and OCD across a range of reported prevalences (Table S3) [33], [34], [35], [36]. Additionally, we provide heritability results converted to the sibling relative risk scale for further interpretation (Table S4). We conducted three primary analyses (univariate TS heritability, univariate OCD heritability, joint OCD and TS bivariate analysis) and five exploratory analyses (partitioning by chromosome, MAF, genic annotation, brain eQTL annotation, age of onset). For each primary analysis, ten permutations of the phenotype were performed and GCTA was run on each permutation to observe the stability of the heritability estimate.
