The PGC consists of a coordinating committee, five disease working groups (ADHD, autism, bipolar, major depressive disorder, and schizophrenia), the cross-disorder working group, and a statistical analysis group that has a CNV subgroup. Working group chairs are: ADHD Dr Stephen Faraone; autism Drs Bernie Devlin and Mark Daly; bipolar disorder Drs John Kelsoe and Pamela Sklar; major depressive disorder Dr Patrick Sullivan; schizophrenia; Dr Pablo Gejman; Statistical analysis Dr Mark Daly; cross-disorder Drs Nick Craddock, Jordan Smoller, and Ken Kendler; and CNV Drs Mark Daly, Steven Scherer, and Jonathan Sebat. Dr Sullivan also chairs the coordinating committee. Additional GWAS for anorexia nervosa and obsessive-compulsive disorder are becoming available and will become part of the PGC in the near future.There are notable computational demands for a project of this scale. We are deeply indebted to Dr Danielle Posthuma (Vrije University Amsterdam) for facilitating the use of a cluster farm in the Netherlands for data warehousing and analysis. The use of this cluster has provided a neutral platform for analyses.