In the brain, Ucn 1 is primarily synthesized in the perioculomotor Ucn 1-containing area (pIIIu), also known as the nonpreganglionic Edinger-Westphal nucleus, and to lesser extent, in the lateral superior olive (Bittencourt et al., 1999; Kozicz et al., 1998; May et al., 2008; Ryabinin et al., 2005; Vaughan et al., 1995; Weitemier and Ryabinin, 2005). The pIIIu exerts its actions via its projections to the lateral septum, dorsal raphe, spinal cord and other brain regions (Bachtell et al., 2003; Bittencourt et al., 1999; Weitemier et al., 2005).
