We carried out a primary GWAS in 74,776 cases and 101,023 controls followed by an Extended GWAS which included additional data for the most significant SNPs (Methods). In the primary GWAS, we combined by meta-analysis i) individual genotypes from a core PGC dataset of 90 cohorts of European (EUR) and East Asian (ASN) ancestry from the Psychiatric Genomics Consortium (PGC) totalling 67,390 cases and 94,015 controls. ii) summary-level data from 7,386 cases and 7,008 controls from 9 cohorts of African-American (AA) and Latino (LAT) ancestry10. We analysed up to 7,585,078 SNPs with MAF ≥ 1% in 175,799 individuals of whom 74.3% were EUR, 17.5% ASN, 5.7% AA, and 2.5% LAT (Supplementary Cohort Descriptions). This primary GWAS identified 313 independent SNPs (linkage disequilibrium (LD) r2 < 0.1) that exceeded genome-wide significance (p<5×10−8) (Extended Data Figure 1; Supplementary Table 1), spanning 263 distinct loci.
