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Chunk #26 — Results — Performance of PRSs in the simulated test datasets

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Generalizing polygenic risk scores from Europeans to Hispanics/Latinos.
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Results are visualized in figures depicting the distributions of the median RMSPEs across the various choices of causal SNPs in each of the simulation scenarios. Figure 2 provides these distributions for two simulation scenarios, where the test dataset was a small admixed population with 40% African ancestry (ADM5,0.4) and the training datasets were a large EA sample and a moderately sized sample of admixed individuals with 20% African ancestry (ADM12,0.2,). Figures corresponding to all other scenarios and settings are provided in the Supplementary Material, Figures S7-S10.