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Chunk #0 — Introduction

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Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6.
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The electroencephalogram (EEG) recorded from the scalp during cognitive tasks contains oscillation patterns in specific frequency bands associated with task processing. These event-related oscillations (EROs) provide a versatile framework to generate coordination and communication during complex brain operations (Buzsaki 2010; Buzsaki & Draguhn 2004); they bind neural ensembles by providing windows of opportunity for neurons to fire enabling functional integration of networks (Fries 2005). EROs in specific frequency bands [delta (1.0-2.5 Hz); theta (3.0-7.0 Hz); alpha (7.5-12.0 Hz); beta (12.5-29.0 Hz); and gamma (>29.0 Hz)] have been attributed to specific cognitive processes during normal and pathological brain function (Babiloni et al. 2011; Basar et al. 2001; Klimesch et al. 2001; Rothenberger 2009). Delta EROs are associated with signal evaluation and decision-making (Basar et al. 1999; Schurmann et al. 2001), while theta EROs are important for processes underlying frontal inhibitory control, conscious awareness, recognition memory and episodic retrieval (Gevins et al. 1998; Klimesch et al. 2001; Klimesch et al. 1994). Theta oscillations have been implicated in sensorimotor integration (Bland & Oddie 2001; O'Keefe & Recce 1993), evaluating loss and gain (Kamarajan