Childhood physical abuse [O.R. 2.93, 95% C.I. 1.88–4.57], but not genotype [O.R. 0.91, 95% C.I. 0.67–1.25], was associated with a diagnosis of lifetime MDD. Genotype interacted with childhood physical abuse to predict lifetime MDD [Table 3, [interaction O.R. 0.34, 95% C.I. 0.14–0.85]]. However, the effect of the interaction was largely attributable to the presence of anhedonia in the context of depression. The interaction between rs1049353 and childhood physical abuse influenced anhedonic MDD in a manner similar to its effect on anhedonia alone, suggesting that the stress adaptive effects of rs1049353 on MDD is attributable to anhedonia (Table 3).
