This study sought to quantify the heritability of both TS and OCD using genome wide genotype data and the REML approach implemented in GCTA [5]. Here we present results from a comprehensive heritability study of these disorders using thorough and stringent quality controls. In addition to obtaining a direct genetic estimate of total heritability for each trait, we also examined the genetic architectures of TS and OCD by partitioning genetic variation according to minor allele frequency, chromosome, and functional annotation. Functional annotations included annotation by genic regions as well as annotation of SNPs correlated with gene expression in parietal cortex and cerebellum, two brain regions for which we had previously generated eQTL data. In addition, we assessed heritability for early onset and adult onset OCD. Lastly, we conducted a bivariate analysis to examine the genetic correlation between OCD and TS.
