variants that influence disease risk, prognosis, or the response to treatment should enable the development of diagnostic and interventional strategies that are safe, effective and as necessary, individualized71, although the value of genetic variants in disease prediction and the steps needed to realize this are widely debated69,70. Given how little has actually been explained of the demonstrable genetic influences on most common diseases, despite identification of hundreds of associated genetic variants, the search for missing heritability provides a potentially valuable path towards further discoveries.
