We evaluated evidence for preferential brain and brain regional expression of the 172 genes identified in Table 1 (body and legend). Brain libraries represented in dbEST contained ESTs that corresponded to 91% (157/172) of these genes. Expression for this set of genes (compared to all genes) displayed nominal significance in thalamus (p < 10-8), amygdale (p = 5.6 × 10-9), hippocampus (p = 2.6 × 10-5), frontal cortex (p = 0.015) and medulla (p = 0.039) using hypergeometric tests (p values were Bonferroni corrected for repeated comparisons). Assessments of the "more reliable" subset of ESTs revealed significant overexpression in whole brain (p = 2.1 × 10-7), amygdala (p = 4.4 × 10-6), hippocampus (p = 0.0011), cerebellum (p = 0.0052), thalamus (p = 0.037) and cortex (p = 0.049) (p-values were Bonferroni corrected).
