Our findings on BRGs were based on regional expression differences that we analyzed using the AHBA. Although the number of AHBA donors is low, we confirmed these expression patterns in UKBEC and GTEx where the number of donors is high. Since most PD studies are limited by the availability of post-mortem brains of PD patients, the two PD datasets in our study had both low numbers of regional samples and donors. Thus, our findings on regional differences in PD patients are less reliable than our findings based on non-neurological controls. Nevertheless, they can still give an indication on how the expression of BRGs changes in brains of PD patients. This study showed that collecting more samples from multiple brain regions in post-mortem PD brains is valuable to get a better understanding of the vulnerability to PD.
