doubled our sample size to perform the largest GWAS meta-analysis of nicotine dependence to date, including 38,602 ever-smokers (28,677 of EUR and 9,925 of African American [AA] ancestries) across 15 studies. We extended our study to include correlations with DNA methylation (DNAm) and RNA expression (RNAexp) of nearby genes across human brain tissues and evaluated associations with a critical smoking-related outcome: lung cancer (total N=81,821 cases and controls).
