brain epigenetic studies have generated interesting findings, they are limited by the small sizes of brain tissue samples and the unavailability of tissues from multiple reward-related brain regions. These limitations will be overcome with the increased access of a larger number of human brain tissues from human brain banks, such as the New South Wales Tissue Resource Centre (NSW-TRC) at the University of Sydney (Australia)98 that collects postmortem brain tissues from schizophrenia or AUD patients and matched healthy control subjects.