In the joint logistic regression analysis, CHRNA5 SNP rs16969968 remains significant (p = 0.0000645) with a similar order of magnitude as its single SNP best model result of p = 0.000028. When controlling for rs16969968 genotype, rs578776 is reduced by an order of magnitude compared to its single SNP result, but it still remains significant in the joint model (p=0.00543). This gives further evidence that there are two distinct susceptibility loci in this gene cluster.
