Significant positive associations were observed among PRS for SCZ, BiP and MDD (SCZ and MDD PRS correlations ranged from 0.2 to 0.4, whereas SCZ and BiP PRS correlations were as high as 0.9). Both BiP and MDD PRS were also associated with EEG coherence. For MDD PRS, the most robust associations were observed with central-parietal high-alpha coherence in females ages 25 and older and in central-temporal high-alpha coherence in males ages 25 and older (Fig. 4 and Supplemental Table 2). For BiP PRS, the most robust associations were observed with central-frontal (FZ-CZ—F3-C3) high-alpha coherence in females ages 12–18 and central-parietal (P8-P4--T8-C4) high-alpha coherence in males 12–18 (Fig. 5 and Supplemental Table 3).
