easier to produce a clinically useful prediction for some autoimmune diseases or late-onset chronic diseases (e.g., coronary artery disease and type 2 diabetes), due to the existence of SNPs with moderate to larger effect sizes. With these being said, as the GWAS sample size continues to grow, we believe that the predictive value of PRS will keep increasing, and PRS-CS(-auto) will demonstrate bigger advantages over existing methods with larger training sample sizes.
