This meta-analysis of GWAS shows highly suggestive association of covert MRI-infarcts with rs2208454 on chromosome 20p12 (p=4.64×10−7). Attempted replication of the top SNP in an independent white sample failed, and additional attempts in larger samples to replicate this finding, as well as associations with other suggestive loci, are needed. Extending replication efforts not only in white but also African-American populations may prove useful for fine mapping purposes. The molecular, clinical, and epidemiological correlates of confirmed associations may permit new insights into the pathophysiology and prevention of covert brain infarcts.
