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Chunk #62 — Results — Analysis of GTEx RNA-seq dataset

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variancePartition: interpreting drivers of variation in complex gene expression studies.
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At the gene-level, variancePartition can prioritize genes based on multiple criteria. For examples, GLMP exhibits higher variation across individuals within blood but low variation in skin (Fig. 5 d). This is consistent of a tissue-specific regulatory variation, and, in fact, the cis-eQTL rs2296374 influences gene expression in blood but not in skin (Fig. 5 e).