11 q14.2. This is consistent with our initial model, Fig. 1 which includes contributions to brain volume variation from both CNVs and alcohol dependent behavior. Duration of drinking is also highly correlated (0.44) with the alcohol use disorder severity component in Fig. 2. This is also consistent with our expectation that duration of drinking can partially co-vary with AUD severity. Certainly, a subject’s brain volume is associated with duration of drinking and possible neurotoxicity effects, however a significant portion of brain volume variation is also associated with CNVs chromosome 11 q14.2.
