highlighted by the fact that it targeted the promoter of a large proportion of the repressed genes in the NAc of heroin abusers. The significant contribution of heroin intake history and OPRM1 polymorphisms to individual differences in ELK1 expression also emphasizes the strong link between MOR and ELK1. Overall, these findings suggest that ELK1 may be a key transcriptional substrate in pathophysiological disturbances relevant to drug addiction.
