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Chunk #77 — Methods — Genetic correlation of PTSD with other traits and disorders

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International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.
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Bivariate LD-score regression (LDSC) was used to calculate pairwise genetic correlation (rg) between PTSD and 235 traits with publicly available GWAS summary statistics on LD Hub12. Summary statistics for PTSD studies were restricted to the EUA meta-analysis, including UKB subjects (23,212 cases, 151,447 controls) and significance was evaluated based on a conservative Bonferroni correction for 235 phenotypes (i.e. correlated traits and traits measured twice in independent studies were counted independently).