The primary focus of our analysis of the COGA-data set was to investigate the course of bipolar I and II with and without CUDs (cannabis abuse and dependence). According to the National Survey on Drug use and Health (NSDUH) [6], the rate of CUD in the US general population accounts for 14.2 million individuals (a prevalence rate of approximately 6.0%). In the current sample, the rate of CUD was 36.1% for bipolar I and II individuals. This finding indicates that bipolar disorders are a considerable risk factor for comorbid CUD. Since this is a sample from a family study, the rate of CUD is higher compared to epidemiological studies (Peters et al., 2014) but lower than rates from clinical samples (47.9%) [9].
