As expected, given existing effect-size estimates, the signals associated with variants within the other established T2D-susceptibility genes, KCNJ11 (rs5215, r2 of 0.9 with rs5219, E23K) and PPARG (rs17036328, r2 of 1 with rs1801282, P12A) are less dramatic (trend test, OR 1.15 and 1.23 respectively, both P=~0.001). These examples illustrate how genuine disease-susceptibility variants can generate association signals which would not attract immediate attention for follow-up in the genomewide context.
