We identified a new genomewide significant locus on chromosome 10 that was associated with vulnerability to cannabis dependence in European ancestry individuals. One of the representative SNPs, rs1409568, showed promising epigenetic evidence and might also contribute to variation in hippocampal volume, which has been related to risk for and resilience to psychiatric disorders, including addictions. Replication, however, was limited to a subset of AA, but not EA, individuals and analyses in the DNS contradicted prior findings for hippocampal volume and did not extend to a broader meta-analysis of hippocampal volume. Therefore, the identification of this chromosome 10 locus should be viewed as preliminary. Future work that aggregates additional cannabis dependent cases and controls, would allow for the detection of smaller effect sizes and a more thorough investigation of comparability of loci across population groups. This is critical, as genomic research into cannabis involvement has lagged behind that of other drugs, despite the pressing public health significance of the problem. Continuing to identify risk factors, both genetic and environmental, that are associated with cannabis dependence is a public health priority, as
