be due to the higher statistical power of the DGN study and the fact that cortical tissue consists of a large variety of cell types, which in aggregate, expresses a large proportion of the transcriptome. Since blood contains a mixture of cell types including immune cells that share characteristics with those in brain, we further assessed the replication rate on three additional tissues, namely subcutaneous adipose, visceral adipose, and liver from the GTEx study28. The replication rates are 0.51, 0.38, and 0.20, respectively, which are indeed lower than that of blood. Additional replication results for different tissues, window sizes, and xQTL types are provided in Table S3.
