locus [27]. All other cisSNPs that associate with brain SLCO1A2 levels have weaker effects that appear to be due to their LD with s11568563, which is a missense coding mutation within SLCO1A2. Whether rs11568563 is merely tagging the functional variant(s) regulating levels of SLCO1A2 or coding changes also influence expressed transcript levels require further investigations. Additionally, MAPT/rs242557 minor allele increased PSP risk [27] and brain MAPT levels (pCer = 9.78×10−3–8.8×10−13, pTCx = 1.1×10−8). MAPT/rs8070723 minor allele associated with lower brain MAPT levels in our eGWAS, decreased PSP risk [27], similar to a PD GWAS [32]. We also found nominally significant increases in brain MOBP levels (pCer = 2.13×10−2–1.71×10−7; pTCx = 1.55×10−2–1.57×10−6) with rs1768208, which increases PSP risk [27].
