To test the association of MDD-associated alleles with each subtype of MDD in GS:SFHS and UKB, summary statistics for major depressive disorder from the Psychiatric Genomics Consortium (minus GS:SFHS, n = 50 455 cases, 105,411 controls; minus UKB, n = 43 204 cases, 95,680 controls)54, UKB and GS:SFHS (from the current study) were used to provide weights for polygenic profile scores (PGS).
