The third evaluation was a rating by informed investigators for 12 genes. These individuals introduced the gene into the literature or had published extensively on it. The informed investigators provide fuller explanations for their rankings in the Supplement. Five genes (AKT1, CHRNA7, DISC1, DRD2, and HTR2A) were rated as highly likely to be a genetic risk factor for schizophrenia (rating ≥4 on a 1–5 scale). With the exception of DRD2, none of the informed ratings ≥4 is supported by empirical results from the older SZGene or the newer PGC mega-analysis.
