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Chunk #21 — Methods — Statistical analysis — Multiple testing correction

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Alcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations.
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False discovery rate (FDR) correction (Benjamini & Hochberg, 1995) was used to adjust for multiple testing. p values were adjusted across all predictors within EXT, INT, and EF separately, and separately across all alcohol milestone predictors of stage-based outcomes. Similarly, FDR correction was used across all INT PGS, all EXT PGS, and the EF PGS in predicting alcohol transitions, and across all alcohol PGS in predicting stage-based symptom onsets. For models examining EF trajectories, FDR correction was employed for the omnibus tests for the main effect of milestone and milestone * age interactions (14 tests), and for the 14 omnibus tests for the main effect of alcohol PGS and PGS * age interactions.