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Chunk #27 — Results — Examining the Moderating Role of Social Support

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The associations between polygenic risk, sensation seeking, social support, and alcohol use in adulthood.
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Results from the path model examining the moderating role of social support in the relationships between alc-GPS, sensation seeking, and alcohol use are presented in Table 3. Results indicated a significant interaction between alc-GPS and friend support in relation to alcohol use (B = −2.38, SE = .93, 95% CI = [−4.11, −1.04], β = .07, p = .01). This GxE effect is robust, remaining statistically significant after adjusting for interactions between alc-GPS and covariates (age, sex, PC1-PC3) and interactions between friend support and covariates (p = .010; see supplemental Table 2). As illustrated in Figure 3 (Panel A), simple slope analyses indicated that alc-GPS was associated with higher alcohol use when friend support was low (−1 SD, B = 2.91, SE = .76, β = .15, p < .001) but not when friend support was high (+1 SD, B = .12, SE = .47, β = .01, p = .799). There was also a significant interaction between sensation seeking and friend support in relation to alcohol use (B = −.27, SE = .10, 95% CI = [−.43, −.12], β