In conclusion, we identified several novel AD risk loci, including the first such associations identified in an AA population. Notably, one finding that maps to chromosome 2 has support from both AA and European-ancestry (EA and German) samples. This novel locus may interact directly with DISC1, a possible schizophrenia37,38 and OD2,31 risk gene whose protein product has a role in cognitive function.39 Additionally, we added to the already considerable evidence for association of variants in the ADH alcohol-metabolizing enzyme genes to AD. Further studies are needed to confirm these associations and to elucidate the functional relationships of the several novel risk loci we identified to AD.
