high levels of all these alternative splicing events were found in the human liver, testes and brain. Additionally these particular human tissues have highly distinct splicing patterns (or sets of spliced isoforms) that differ from most other tissues. Another study (de la Grange, et al., 2010) also demonstrated that alternative splicing is especially prevalent in the brain and testes compared to other tissues and organs. It has been shown, while comparing splicing factors and exon expression profiling across 11 human tissues, that the higher prevalence of alternative splicing might be determined by a larger number of genes, including splicing factors, which are expressed in a subset of tissues and in the brain in particular.
