two of the following three conditions: A fractional publication count (28) above 5, three or more Gene RIF, ‘Reference Into Function’ annotations (https://www.ncbi.nlm.nih.gov/gene/about-generif), or 50 or more commercial antibodies, as counted in the Antibodypedia portal (29). The fourth category, Tdark, currently includes ∼31% of the human proteins that were manually curated at the primary sequence level in UniProt, but do not meet any of the Tclin, Tchem or Tbio criteria. Figure 1 shows the TDL count changes between version 3 and 6.7.
