were retained: (1) age-by-baseline drinking, and (2) age-by-mood symptoms. Significant two-way interactions were probed using simple slopes analysis[39]. In addition, the effect of study membership and two-way interactions between study membership and covariates were also included in all models (Supplementary Table 2). Similar to our previous analyses[6] we did not include treatment condition as a covariate in the models because we were primarily interested in patterns of change regardless of treatment condition. In addition, the three studies included 10 different treatments, however participants in any given study could only be assigned to a limited set of treatment options (e.g., placebo, acamprosate, naltrexone, MM, or CBI in COMBINE; CBT, MET, or TSF in MATCH; MET or SBNT in UKATT).
