The aim of our study was to search in a sample of OCD patients for the presence of 15q11-13 or 22q11.2 microrearrangements using multiplex ligation-dependent probe amplification (MLPA). This is the first study to systematically screen these two copy number variants (CNVs) in OCD patients. MLPA has the ability to analyze up to 50 targets in a single reaction and to detect both deletions and duplications. The efficacy of MLPA in detecting 15q11-q13 and 22q11.2 microrearrangements has been previously established [22,23]. We thus applied MLPA to screen our dataset for 15q11-q13 and 22q11.2 deletions/duplications.
