The results for variants mapped to TTC12 for AD+DD were similar to our previously published results in the AD-all analyses, but yielded much greater statistical significance (e.g., with the p-value being reduced from 0.00067 to 0.000023 for the A-G-A-A haplotype at markers T3-T6; see Table 5), and additional specific haplotypes being significant, whereas in the earlier analysis they were not. On the other hand, TTC12 was not observed to harbor risk variants for AD-only, a finding that was probably not due to lack of power, as the sample size was greater for AD-only than for AD+DD.
