(Dnmt3a, p = .04), both of which are critical for maintenance and de novo methylation of genes involved in fetal programming. Increased expression of the following factors was found after PAE in the proliferating NPC cultures: fibroblast growth factor 13 (Fgf13, p = .02), important for microtubule stabilization; necdin (Ndn, p = .004), an imprinted gene that regulates quiescence; and SRY-box containing gene 3 (Sox3, p = .02), which regulates NPC maintenance and proliferation and acts to inhibit differentiation.
