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Chunk #6 — RESULTS — Large CNVs are overrepresented in obese case subjects.

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Large copy-number variations are enriched in cases with moderate to extreme obesity.
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in case and control subjects in Table 2, and the signal intensity patterns are provided in supplementary Fig. 3 as a visual means of validation. We also assessed whether large and rare gene-disrupting deletion CNVs tend to be enriched in case versus control subjects. Not surprisingly, the ORs for conferring risk of obesity are even higher for this group of CNVs (2.7 [0.47–27.1] for >1 Mb CNVs, infinity for >2 Mb CNVs) (Table 2), though this does not reach statistical significance due to the rare nature of the events.