the brain. ECs are a class of lipid-derived neuromodulators that serve as retrograde transmitters in central synapses. Research within the past decade has made it clear that ethanol interacts with the EC system, and a growing body of evidence suggests that the function of the EC system may be altered in alcohol dependence. In this review, we will begin by briefly discussing the early studies that demonstrated a link between the physiological and behavioral effects of cannabis and ethanol. Next we will cover the findings indicating that the EC system is a molecular target for ethanol and how the function of this neuromodulatory system is altered following chronic ethanol. Along these lines, we will attempt to place the behavioral ramifications of altered EC signaling in the context of circuitry associated with addictive processes. Finally, emerging topics in the fields of EC signaling and alcohol abuse will be discussed as future directions for research.
