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Chunk #60 — THEORETICAL DERIVATIONS — IMPACT OF LD ON POWER

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Disease model distortion in association studies.
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The previous section describes the impact of LD on the disease effect parameters. We now examine how this impacts the power of the corresponding tests. Derivations of the noncentrality parameters for each test are shown in Appendix A. Combining these with the parameter-LD relationships from the previous section allows us to give approximate expressions for the power when testing at marker SNPs.